- Increases blood perfusion, permeability, pH, pO2
- Reduces tumor hypoxia, making tumor cells more radiosensitive
- Suppresses DNA repair mechanisms
- Cytotoxic, including cells in the S-phase
- Increases drug uptake into tumor cells
- Overcomes various modes of drug resistance
- Increases the delivery of macromolecules and nanoparticle drug carriers to tumors HT stimulates tumor-specific immune responses
